Hydroxylated dendrimer nanogels co-deliver drugs and cytokines for chemoimmunotherapy of glioma.

ABSTRACT: Developing simple blood-brain barrier (BBB)-crossing nanoplatforms capable of overcoming the restrictions of BBB and the immunosuppressive tumor microenvironment (TME) still remains challenging. Herein, we develop a dual pH/reactive oxygen species-responsive dendrimer nanogel (DNG) platform based on generation 3 poly(amidoamine) (G3 PAMAM) dendrimers for co-delivery of the hypoxia-activated prodrug tirapazamine (TPZ) and the immunomodulatory cytokine interferon-gamma (IFN-γ). First, DNGs were synthesized by crosslinking hydroxylated G3 PAMAM dendrimers partially modified with phenylboronic acid (PBA) with dual PBA-terminated poly(ethylene glycol) via a reverse microemulsion method, followed by physical loading of TPZ within the DNGs and surface complexation of IFN-γ. The prepared DN

SUBMITTER: Wang J 

PROVIDER: S-EPMC12719226 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature