WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface.

ABSTRACT:

Background

Pregnancy maintenance requires precise immunoregulation at the maternal-fetal interface, where M2-polarized decidual macrophages (dMφ) support immune tolerance. While canonical WNT signaling is reported to regulate macrophage polarization, its specific function within the decidual immune microenvironment remains insufficiently understood. Moreover, whether individual ligands such as WNT16 can epigenetically reprogram decidual macrophage responses has yet to be elucidated.

Methods

Endometrial stromal cells (ESCs) from non-pregnant women and decidual stromal cells (DSCs) from normal pregnancies (NP) and recurrent spontaneous abortion (RSA) were accessed for WNT16 expression by RT-qPCR, ELISA and immunohistochemistry. The effects of WNT16 on macrophages were examined

SUBMITTER: Chang L 

PROVIDER: S-EPMC12719274 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature