TAS1R3 influences GTPase-dependent signaling in human islet β-cells.

ABSTRACT:

Background

The taste receptor type 1 member 3 (TAS1R3), a G protein-coupled receptor (GPCR), is expressed in pancreatic islet β-cells where it may influence intracellular signaling pathways critical for β-cell function. Although TAS1R3 is known to couple to heterotrimeric G-proteins, its potential influence on small GTPases-key regulators of vesicle trafficking, cytoskeletal remodeling, and signal transduction-remains unexplored. Investigating how TAS1R3 modulates small GTPase activity could uncover mechanisms by which β cells regulate insulin secretion and adapt to metabolic cues.

Objective

We questioned whether activation of endogenous TAS1R3 in human islets or clonal human β-cells are necessary for glucose-stimulated insulin secretion via activation of small GTPase

SUBMITTER: Veluthakal R 

PROVIDER: S-EPMC12719281 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature