Clinical differential analysis of severe complications thrombotic microangiopathy and acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.

ABSTRACT:

Background

Identifying the early markers of transplant-associated thrombotic microangiopathy (TA-TMA) and mild or severe acute graft-versus-host disease poses a significant challenge in the differential diagnosis of severe complications after allo-hematopoietic stem cell transplantation (allo-HSCT).

Methods

We conducted an analysis of 109 patients who developed TA-TMA, grade I-II aGVHD , and grade III-IV aGVHD following allo-HSCTs at our center between 2019 and 2024. Clinical features, laboratory data and outcomes were compared among these groups.

Results

The median diagnostic time for TA-TMA was 94 days post-transplant, with median survival of 1 month for TA-TMA and 2 months for grade III-IV aGVHD, significantly shorter than 5 months for grade I-II aGVHD. Survival cu

SUBMITTER: Wang YY 

PROVIDER: S-EPMC12719282 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature