Genetic Overlap Between DSM-IV Major Depressive Disorder and Suicidal Behaviors: Evidence from Polygenic Risk Scores in Young Adult Twins.

ABSTRACT: Suicidal thoughts and behaviors (STBs) represent a significant public health concern. This study aimed to examine the extent to which polygenic risk scores (PRSs) for suicide attempt and major depression (MD) explain variance in suicidal ideation, plans, and attempts among young adult twins. Data from 2876 participants of European ancestry in the Brisbane Longitudinal Twin Study were analyzed. PRSs for MD and suicidal behavior (SB PRS) were calculated. Multivariate twin modeling was used to estimate genetic and environmental influences on DSM-IV Major Depressive Disorder (MDD) diagnosis and STBs, as well as their associations with PRSs. Heritability estimates were higher for STB phenotypes (51-80%) compared to DSM-IV MDD (39-41%). The MD PRS showed more consistent genetic correlations with

SUBMITTER: Gillespie NA 

PROVIDER: S-EPMC12719343 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature