Emergence of Next-Generation Sequencing for Laboratory Diagnosis of Talaromyces marneffei.

ABSTRACT: The first case of Talaromyces marneffei infection diagnosed by next-generation sequencing (NGS) was reported in 2018. By 31st December 2024, the number of T. marneffei infections picked up by NGS has increased to a total of at least 241. Most cases were reported from China, reflecting both the regional importance of this infection and its widespread use of NGS for laboratory diagnosis of infectious diseases. Among the cases with clinical details reported, 136 were HIV-negative, which was probably the main reason why T. marneffei was not suspected and the diagnosis was subsequently made with the use of NGS. For these 136 HIV-negative patients, 62 were confirmed to have other forms of immunodeficiencies, such as anti-interferon gamma autoantibodies and post-renal/liver transplantation. The c

SUBMITTER: Xing F 

PROVIDER: S-EPMC12719348 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature