Unraveling the Significance of Fecal MicroRNA Profile in Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD), a complex neurodegenerative disorder characterised by progressive cognitive decline, affects millions globally. With no current cure, treatment focuses on symptom management and slowing disease progression. Early identification is therefore crucial. Fecal microRNA (miRNA) analysis is emerging as a promising non-invasive diagnostic tool. Evidence suggests that miRNAs present in fecal samples may regulate gene expression linked to AD pathology, impacting cellular functions and disease progression. Dietary factors critically influence gut microbiota composition and diversity, affecting brain health via the gut brain axis. Macronutrients such as carbohydrates, proteins, and fats modulate miRNA expression and gut microbiota, influencing AD risk. High-fat diets can incr

SUBMITTER: Katuwawala K 

PROVIDER: S-EPMC12719353 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature