The role of eplet matching in solid organ transplantation.

ABSTRACT:

Introduction

Donor-recipient compatibility remains a central determinant of transplant success, yet conventional antigen-level human leukocyte antigen (HLA) matching provides limited resolution for predicting alloimmune risk. Molecular matching at the eplet level, which quantifies structural motifs on HLA molecules recognized by B- and T-cells, has emerged as a promising strategy to refine immunologic risk assessment.

Methods

We conducted a scoping review of 98 studies encompassing 286,101 solid organ transplant (SOT) recipients across kidney, heart, lung, liver, pancreas, and combined grafts. Data on HLA typing approaches, eplet mismatch (epMM) algorithms, thresholds, and associations with clinical outcomes were systematically extracted and synthesized.

Results

The m

SUBMITTER: Stogner VA 

PROVIDER: S-EPMC12719434 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature