Successful ECMO support for cardiogenic shock induced by immune checkpoint inhibitor-associated myocarditis: a case report and literature review.

ABSTRACT:

Objectives

Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare but potentially fatal immune-related adverse event that can rapidly progress to life-threatening arrhythmias and cardiogenic shock, often necessitating mechanical circulatory support. Extracorporeal membrane oxygenation (ECMO) has emerged as a critical life-saving intervention in such cases. However, the role of ECMO in treating ICI-associated myocarditis remains underexplored, with limited literature available.

Methods

We present a case of fulminant ICI-associated myocarditis with cardiogenic shock successfully managed with ECMO. Additionally, we review and summarize data from 13 ECMO-assisted patients with ICI-associated myocarditis to provide insights into the clinical characteristics, managemen

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12719444 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature