Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice.

ABSTRACT: The postmenopausal period is associated with an increased tendency to gain weight. This may be due to disturbances in appetite regulation, mainly in the hypothalamus and nutritional behaviors, as well as persistent neuroinflammation resulting from estrogen deficiency. Research indicates that physical activity may counteract estrogen deficiency by improving hypothalamic regulation of appetite and inflammation, thereby promoting better energy balance and decreasing the risk of weight gain after menopause. We investigated whether voluntary wheel running (VWR) impacts factors related to appetite, energy homeostasis, and neuroinflammatory changes induced by ovariectomy (OVX). Thus, 13-month-old female mice underwent OVX, creating a comprehensive model of reproductive aging in females. Ovariecto

SUBMITTER: Grabowski M 

PROVIDER: S-EPMC12719451 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature