Comparative efficacy and safety of teriparatide versus bisphosphonates in osteoporosis: a meta-analysis.

ABSTRACT:

Objectives

This meta-analysis systematically compared the efficacy and safety of teriparatide and bisphosphonates in treating osteoporosis (OP) to inform optimal treatment strategies.

Methods

A comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar from inception through October 2024. Randomized controlled trials comparing teriparatide and bisphosphonates for OP were included. Primary outcomes included vertebral/non-vertebral fracture risk reduction and lumbar spine/femoral neck bone mineral density (BMD) improvements. Data were analyzed using RevMan 5.3, with dichotomous data assessed via odds ratios (OR) and continuous data via mean differences (MD), both reported with 95% confidence intervals (CI).

Results<

SUBMITTER: Jin H 

PROVIDER: S-EPMC12719462 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature