The effect of disulfidptosis induced by glucose starvation in SLC7A11^high ovarian cancer cells.

ABSTRACT:

Objective

Disulfidptosis is a glucose deprivation-induced cell death mechanism driven by disulfide stress-mediated actin cytoskeleton disintegration. This study explored whether SLC7A11^high ovarian cancer (OC) undergoes disulfidptosis under conditions of glucose starvation. This study aimed to provide a new treatment option for OC.

Methods

Initially, we carried out an assay to assess the cell viability of IOSE 80 and OVCAR 3 cells under conditions of glucose sufficiency and starvation. Subsequently, we examined the difference in SLC7A11 expression between the two cell types under the specified conditions. The intracellular NADP⁺/nicotinamide adenine dinucleotide phosphate (NADPH) ratio and the oxidized glutathione disulfide/reduced glutathione (GSSG/GSH

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12719518 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature