Functional and Transcriptional Disruption of Hepatic ABC Transporters by Environmentally Relevant Short-Chain Per- and Polyfluoroalkyl Substances (PFAS).

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) represent a large class of > 11,000 synthetic organofluorine compounds that are globally distributed and consistently detected in human serum. Recent studies suggest that environmentally relevant exposures to short-chain PFAS can disrupt ATP-binding cassette (ABC) transporters, which regulate xenobiotic disposition and are critical for human health. This study examined the effects of short-term (45 min) and long-term (48 h) exposures to 1 nM or 1 µM of four short-chain PFAS, perfluorobutanesulfonic acid (PFBS), perfluorohexanoic acid (PFHxA), perfluorohexanesulfonic acid (PFHxS), and 6:2 fluorotelomer alcohol (6:2 FTOH), using differentiated HepaRG hepatocytes. Functional assays evaluated changes in efflux activity, while gene expression analysis

SUBMITTER: Collier GE 

PROVIDER: S-EPMC12719549 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature