Prussian Blue Nanoparticles Promoting Diabetic Bone Regeneration via Mitochondrial Recovery.

ABSTRACT: Objective: This work aims to develop Prussian blue (PB) nanoparticles that mitigate bone marrow mesenchymal stem cell (BMSC) senescence and alleviate bone loss in type 2 diabetes (T2D). Impact Statement: PB nanozymes are established as a targeted therapeutic strategy for maintaining bone quality in T2D-addressing an unmet clinical need through innovative nanomaterial design. Introduction: Diabetes is associated with a higher risk of fractures through distinct mechanisms. Elevated blood sugar levels and excessive nutrition in T2D trigger reactive oxygen species (ROS) overproduction that impairs mitochondrial function, induces BMSC senescence, and compromises osteogenic potential. Engineered as artificial enzyme counterparts, nanozymes effectively eliminate ROS while cir

SUBMITTER: Gu A 

PROVIDER: S-EPMC12719558 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature