Predictive and prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: a real-world study from Vietnam.

ABSTRACT:

Background

The clinical validity of tumor-infiltrating lymphocytes (TILs) has been investigated extensively in triple-negative breast cancer (TNBC). However, inconsistent cutoff values across studies limit its clinical application.

Objective

To determine the optimal TILs cutoff predicting pathological complete response (pCR) and event-free survival (EFS) in Vietnamese TNBC patients undergoing neoadjuvant chemotherapy (NACT).

Design

A single-center, retrospective cohort study of 106 stage II-III TNBC patients treated with NACT at Ho Chi Minh City Oncology Hospital between January 2022 and May 2023.

Methods

Stromal TILs (sTILs) were evaluated on pre-treatment biopsy specimens using the International TILs Working Group guideline. The optimal cutoff was determined

SUBMITTER: Tran LDN 

PROVIDER: S-EPMC12719585 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature