The organic cation transporters 1 and 2 mediate ethanolamine cellular efflux and control systemic phosphatidylethanolamine level.

ABSTRACT: The organic cation transporters (OCTs) OCT1 on the basolateral membrane of enterocytes and hepatocytes and OCT2 on the basolateral membrane of proximal tubular cells are essential in regulating systemic micronutrient levels, while also safeguarding tissues by preventing the buildup of potentially harmful endogenous metabolites, drugs, and xenobiotics. In the present work, we integrated in vivo comparative metabolomics and lipidomics analyses of serum from WT and Oct1/2^-/- mice with in vitro uptake measurements in HEK293 cells overexpressing OCT1 or OCT2, to identify and characterize novel endogenous substrates of OCT1/2. Among the significant metabolite changes, ethanolamine in the serum of Oct1/2^-/- mice was approximately 70% lower than in WT mice. The ethanolamine i

SUBMITTER: Schubert J 

PROVIDER: S-EPMC12719660 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature