Leveraging microbiota-metabolites to reduce inflammation and promote functional recovery following spinal cord injury in female mice.

ABSTRACT: Spinal cord injury induces extensive neurological impairment and drives systemic and tissue-level inflammatory responses that accelerate secondary systemic damage. Emerging evidence suggests that gut microbiota-derived metabolites can influence post-injury inflammation, presenting a potential therapeutic approach. This study examines whether the tryptophan-derived metabolites indole and indole-3-propionic acid modulate inflammatory responses and improve outcomes following spinal cord injury. Female C57BL/6J mice received a severe thoracic-8 contusion-compression injury and were administered indole or indole-3-proprionic acid daily via oral gavage for the duration of the observation period. In an acute cohort, 7 days post-injury, neither treatment altered plasma inflammatory profiles relati

SUBMITTER: Douthitt AJ 

PROVIDER: S-EPMC12719675 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature