Glial activation and increase in cerebral pro-inflammatory cytokine expression in a female animal post-COVID model.

ABSTRACT:

Introduction

Many COVID-19 survivors suffer long-term multi-organ damage leading to some symptoms such as brain fog. Around 25 % of patients report persistent memory loss, concentration difficulties, or other cognitive impairments after a SARS-COV-2 infection. Animal models are crucial for studying the pathophysiology of post-acute COVID-19 sequelae (PASC).

Objective

To assess the presence of neuro-inflammatory and glial activation biomarkers in brain tissue after a SARS-CoV-2 infection in an animal model to better understand the pathophysiology of neurocognitive symptoms.

Methods

Twelve C57BL/6 female hACE2 mice infected with SARS-CoV-2 Omicron variant (BA.1.17 lineage) and eleven non-infected female mice were included. Different proteins evaluating the innate immune

SUBMITTER: Prados SF 

PROVIDER: S-EPMC12719681 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature