Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity.

ABSTRACT:

Objective

To investigate the relationship between free-living glucose metrics obtained with continuous glucose monitoring (CGM) and validated indices of insulin resistance and insulin secretion in individuals with obesity: OB(+T2D) or OB(-T2D) for with and without type 2 diabetes, respectively.

Research design and methods

Thirty-seven individuals (17 OB(+T2D) and 20 OB(-T2D) wore a CGM device and had a 2-h oral glucose tolerance test (OGTT). Of these, 27 also underwent a two-step hyperglycemic-euglycemic clamp. CGM metrics calculated with EasyGV software were correlated with indices of insulin secretion and insulin resistance from OGTT and clamp.

Results

CGM metrics, such as mean and glycemic variability indices, were higher in OB(+T2D) than in OB(-T2D) (P < 0.001). C

SUBMITTER: Belfort-DeAguiar R 

PROVIDER: S-EPMC12719714 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature