The Role of Adaptive and Innovative Trial Designs in Diabetes Research: A Scoping Review.

ABSTRACT:

Background

Adaptive and master protocol clinical trials offer significant advantages for diabetes research, including enhanced efficiency and personalized treatment strategies.

Purpose

This scoping review aimed to systematically map the use of adaptive and master protocol designs in interventional trials for type 1 and type 2 diabetes, identify research gaps, and highlight opportunities for broader implementation.

Data sources

A systematic literature search was performed using MEDLINE, Embase, CENTRAL, Emcare, Global Health, Web of Science, and clinical trial registries. Gray literature searches complemented database findings.

Study selection

Studies using adaptive, platform, basket, or umbrella trial designs in people with type 1 or type 2 diabetes were includ

SUBMITTER: Goshrani A 

PROVIDER: S-EPMC12719716 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature