A naturally isolated symbiotic <i>Lactobacillus murinus</i> suppresses multidrug-resistant <i>Campylobacter jejuni</i> via microbial metabolites.

ABSTRACT: Multidrug-resistant Campylobacter jejuni (MDR C. jejuni), the leading cause of food-borne gastroenteritis worldwide, poses a significant threat to public health and food safety. The intestinal microbiota prevents MDR C. jejuni colonization, but the specific mechanisms remain poorly understood. In this study, we performed a multi-omics analysis of the gut microbiota in C57BL/6 mice, combined with in vitro experiments, to investigate the role of gut microbiota in C. jejuni colonization. Treatment with tylvalosin, a new macrolide, altered the gut microbiota composition, reducing Bifidobacterium longum communities and decreasing levels of short-chain fatty acids (acetic acid, propionic acid, n-butyric acid, i-butyric acid, and i-va

SUBMITTER: Wang J 

PROVIDER: S-EPMC12719756 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature