Central nervous system tuberculosis: characteristics, risks, and outcomes in California adults, 2010-2022.

ABSTRACT:

Background

Central nervous system (CNS) tuberculosis (TB) is rare and causes substantial morbidity and mortality. We quantified the frequency, characteristics, outcomes, and risks associated with CNS TB.

Methods

We performed a retrospective analysis of culture-confirmed TB in adults reported to the California TB Registry during 2010-2022 to compare individuals with CNS TB vs. non-CNS TB. We used a causal diagram and modified Poisson model with robust variance to estimate the adjusted relative risk of CNS TB vs. non-CNS TB among people with TB caused by Mycobacterium bovis vs. non-M. bovis M. tuberculosis complex. We also identified risk factors for death with CNS TB.

Results

There were 21,117 TB cases reported; 382 (1.8 %) involved the CNS. Compared to t

SUBMITTER: Parchinski K 

PROVIDER: S-EPMC12719761 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature