Qianzheng powder promotes facial nerve regeneration via BDNF/TrkB/CREB pathway activation.

ABSTRACT:

Introduction

Facial nerve injury (FNI) is a common peripheral neuropathy that severely impairs facial function and quality of life. Qianzheng Powder (QZP) is a traditional Chinese herbal formula used to treat facial paralysis clinically, yet its neuroprotective mechanisms remain unclear. This study aims to evaluate the therapeutic effects of QZP on FNI and potential underlying mechanisms.

Methods

A FNI model was established in male C57BL/6 mice by performing facial nerve crush surgery. QZP (3.51 g/kg) was administered orally once daily for 14 days post-surgery. Facial function was assessed behaviorally. Tissue samples were collected on day 21 for histological evaluation, qPCR and Western blotting. Liver and kidney safety were also assessed via H&E staining and serum biochemi

SUBMITTER: Chen L 

PROVIDER: S-EPMC12719776 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature