Assessing cardiovascular benefits of intensive blood pressure lowering in high-risk undiagnosed HFpEF patients.

ABSTRACT:

Aims

Heart failure with preserved ejection fraction (HFpEF) is often underdiagnosed. This study evaluates the HFpEF-ABA score's ability to identify high-risk, undiagnosed HFpEF subgroups with elevated cardiovascular event rates and assesses the impact of intensive blood pressure control in these populations.

Methods

A post-hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) was performed. The HFpEF-ABA score identified high-risk individuals with undiagnosed HFpEF. Cox proportional hazards regression was used to examine interactions between HFpEF-ABA score groups and intensive blood pressure control on major cardiovascular outcomes. The primary outcome was a composite of myocardial infarction (MI), acute coronary syndrome not resulting in MI, stroke, acute

SUBMITTER: Liu X 

PROVIDER: S-EPMC12719812 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature