Gastroesophageal reflux disease and risk of atrial fibrillation/flutter: Implications for heart failure progression.

ABSTRACT:

Aims

While observational studies suggest an association between gastroesophageal reflux disease (GERD) and atrial fibrillation/flutter (AF/AFL), the causal relationship and mechanisms remain undefined. This study employed Mendelian randomization (MR) to assess bidirectional causal relationships and explore potential implications for heart failure (HF) risk.

Methods and results

A bidirectional two-sample MR analysis was conducted using genome-wide association study (GWAS) summary data from European populations (GERD: 129,080 cases and 473,524 controls; AF/AFL: 22,068 cases and 116,926 controls; Obesity: 4793 cases and 209,884 controls). Genetic instruments were selected for GERD and AF/AFL, with inverse variance weighting (IVW) as the primary analytical method to examine caus

SUBMITTER: Hu W 

PROVIDER: S-EPMC12719815 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature