The utility of urine biomarkers in diuretic resistance prediction in heart failure hospitalization.

ABSTRACT:

Aims

Loop diuretic resistance (LDR) in patients with heart failure hospitalization (HHF) is associated with worse clinical outcomes. The study aimed to assess the predictive ability of urine biomarkers for LDR in HHF.

Methods

Consecutive patients with congestive HHF were included. Congestion was defined as the presence of oedema, ascites, or pleural effusion. LDR was defined as persistent congestion on the fourth day of hospitalization despite high intravenous loop diuretic doses. Urine biomarkers [Kidney Injury Molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), uromodulin, glutathione S-transferase Pi (pi-GST) and aquaporin-2], transthoracic echocardiography (TTE), clinical and biochemical parameters on the first and fourth days of hospital stay were evaluated.

Resu

SUBMITTER: Imiela T 

PROVIDER: S-EPMC12719833 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature