Impact of epicardial adipose tissue on myocardial function and structure in patients with severe aortic valve stenosis.

ABSTRACT:

Aims

Epicardial adipose tissue (EAT) is closely associated with the development of heart failure and adverse myocardial remodelling. In patients with severe aortic valve stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), increased EAT has been identified as a predictor of adverse outcomes; however, the underlying pathophysiological mechanisms remain unclear. This study aims to explore the effects of increased EAT volumes on myocardial remodelling and dysfunction in patients with severe AS.

Methods and results

One hundred thirty-seven patients with severe AS (median age 80 years, 62% male) underwent cardiac magnetic resonance imaging (CMR) prior to TAVR. Myocardial volumes and function as well as EAT volumes were quantified from CMR acquisitions. The coho

SUBMITTER: Gronwald J 

PROVIDER: S-EPMC12719855 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature