Guideline-directed medical therapy after revascularization and outcomes in ischaemic cardiomyopathy.

ABSTRACT:

Aims

Guideline-directed medical therapy (GDMT) remains the cornerstone for treating patients with heart failure (HF) and reduced ejection fraction (HFrEF) and coronary artery disease (CAD). However, real-world implementation of GDMT (GDMTi) is suboptimal. This subanalysis of the RevascHeart study evaluates the impact of GDMTi on long-term mortality in patients with de novo ischaemic heart failure (HF) undergoing revascularization.

Methods

Among 409 patients with HFrEF (left ventricular ejection fraction ≤40%) and CAD, 275 one-year survivors who underwent revascularisation shortly after index HF admission were included in this landmark analysis (LA). GDMTi at 12 months was defined as initiation of each recommended drug class, regardless of dose. Primary endpoints were all-cau

SUBMITTER: Moliner-Abos C 

PROVIDER: S-EPMC12719861 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature