Pathogenic glycosyltransferase genes and potential therapeutic drugs in pressure overload-induced heart failure.

ABSTRACT:

Aims

Protein glycosylation regulated by glycosyltransferases is an important type of post-translational modification. The role of the glycosyltransferase genes (GTGs) in heart failure (HF) remains unclear and requires further investigation.

Methods

Differential expression analysis was performed on the transverse aortic constriction (TAC)-related dataset GSE36074 to screen out the differentially expressed GTGs. Enrichment and protein-protein interaction analyses explored their functional mechanisms and interconnections. Pearson correlation analysis revealed the relationship between GTGs and pathological cardiac remodelling. The upstream miRNAs of GTGs were predicted using corresponding online databases, and the downstream target genes were identified by weighted correlation n

SUBMITTER: Wu J 

PROVIDER: S-EPMC12719869 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature