TIPE2 deficiency enhances macrophage phagocytosis of tumor cells.

ABSTRACT:

Introduction

Understanding the negative regulatory mechanisms of immune cell functions is essential for developing effective tumor immunotherapy strategies. Macrophages play a crucial role in antitumor immunity; however, the mechanisms that negatively regulate their antitumor functions remain incompletely understood. TIPE2 is known to be a critical regulator of various immune cells, but its role as a negative regulator of macrophage antitumor functions has not yet been established.

Objectives

This study aims to investigate whether TIPE2 negatively regulates the antitumor functions of macrophages and to elucidate the mechanisms involved.

Methods

We used a mouse model of hepatic tumor metastasis and a subcutaneous tumor model to evaluate the impact of TIPE2 on macrophag

SUBMITTER: Ma Z 

PROVIDER: S-EPMC12719894 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature