Ventilation-Weaning Protocols in Children Admitted to Pediatric Intensive Care Units: Systematic Review of Randomized Trials.

ABSTRACT:

Objective

To determine whether implementing a ventilator weaning protocol in a Pediatric Intensive Care Unit (PICU) can decrease the duration of invasive mechanical ventilation (IMV), the PICU and hospital length of stay (LOS), mortality rates, and extubation failure compared to usual care.

Methods

PubMed, EMBASE, CINAHL, Web of Science, and Cochrane Central Register of Controlled Trials were searched. The randomized controlled trials reporting a weaning protocol compared with usual care in a PICU were selected. The risk of bias and the certainty of evidence were assessed. The duration of IMV was the main outcome, and PICU and hospital LOS, extubation failure, and mortality were the secondary outcomes.

Results

Seven trials were included (n = 11,742). The implemented p

SUBMITTER: Almeida SC 

PROVIDER: S-EPMC12719932 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature