The Neurocircuitry of Cannabis Cue Reactivity in Cannabis Use Disorder: A Functional Neuroimaging Study.

ABSTRACT:

Background

A common feature of cannabis use disorder (CUD) is an intense reactivity to cannabis cues, which are becoming increasingly visible due to the growth in its decriminalization, accessibility, and marketing of cannabis products. The brain's automatic reactivity to cannabis cues can trigger craving and subsequent use. In this study, we aimed to test neural activity during cannabis cue reactivity in non-treatment-seeking individuals with moderate-to-severe CUD and past attempts to cut down/quit.

Methods

The study examined 65 individuals with moderate-to-severe CUD and 43 control participants, with a functional magnetic resonance imaging cannabis cue-reactivity task and assessment of mental health and substance use as well as cognitive testing. Group differences in neur

SUBMITTER: Lorenzetti V 

PROVIDER: S-EPMC12720038 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature