Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments.

ABSTRACT: Understanding the oscillating behaviors that govern organisms' internal biological processes requires interdisciplinary efforts combining both biological and computer experiments, as the latter can complement the former by simulating perturbed conditions with higher resolution. Harmonizing the two types of experiment, however, poses significant statistical challenges due to identifiability issues, numerical instability, and ill behavior in high dimension. This article devises a new Bayesian calibration framework for oscillating biochemical models. The proposed Bayesian model is estimated relying on an advanced Markov chain Monte Carlo (MCMC) technique which can efficiently infer the parameter values that match the simulated and observed oscillatory processes. Also proposed is an approach t

SUBMITTER: Hwang Y 

PROVIDER: S-EPMC12720118 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature