Erianin Abrogates Cancerous Vasculogenic Mimicry Through Targeting m5C Methylase NSUN2 in Uveal Melanoma.

ABSTRACT:

Purpose

The regulatory role of N5-methylcytosine (m5C) RNA modification is of vital importance for the metabolism of RNA. As a natural product isolated from Dendrobium chrysotoxum Lindl., erianin shows promising therapeutic efficacy in cancer therapy. Herein, we determined that erianin serves as a naturally occurring NOP2/Sun RNA methyltransferase 2 (NSUN2) inhibitor in malignant vascular formation in uveal melanoma.

Methods

Natural product library screening was conducted to explore the effects of natural product monomers on uveal melanoma cells. An intraocular xenografts model was established to examine the effect of erianin. Immunoprecipitation and mass spectrometry (IP-MS) and molecular docking analyses were used to identify NSUN2 as the target of erianin. m5C-methylated

SUBMITTER: Zuo S 

PROVIDER: S-EPMC12720188 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature