External validation of a microRNA thyroid classifier: a real-world prospective study.

ABSTRACT:

Introduction

Thyroid nodules are common, affecting approximately 50% of individuals. These nodules are often discovered incidentally and exhibit benign characteristics. Following a suspicious ultrasound, a fine-needle aspiration biopsy (FNAB) is performed to assess the risk of malignancy. However, approximately 30% of cases are classified as indeterminate by cytology. In response, the development of molecular tests has refined malignancy risk assessment and reduced the need for diagnostic surgeries.

Objective

To independently evaluate the real-world clinical utility and the diagnostic performance of a microRNA-based molecular test (mir-THYpe full) in improving diagnostic accuracy and avoiding unnecessary surgeries in indeterminate thyroid nodules.

Methods

This is the

SUBMITTER: Gregorio Arnaut Lima E 

PROVIDER: S-EPMC12720197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature