Acute Pain After Total Knee Arthroplasty: 2-Arachidonoylglycerol Tone and Endocannabinoid/Eicosanoid Crosstalk.

ABSTRACT:

Background

Total knee arthroplasty (TKA) is a surgical procedure that induces intense acute postoperative pain, but the mechanisms that amplify post-TKA pain remain incompletely understood. Endocannabinoids, such as 2-arachidonoylglycerol (2-AG), are endogenous lipids that can produce antinociceptive effects. However, hydrolysis of 2-AG by monoacylglycerol lipase (MAGL) generates arachidonic acid, the precursor to a host of eicosanoids that enhance pain. The presence of this metabolic pathway suggests that individuals with elevated 2-AG levels may be primed to develop greater postoperative pain.

Methods

The primary goal of this prospective study was to determine if intraoperative 2-AG levels in the synovial fluid (SF) and cerebrospinal fluid (CSF) of TKA patients are associa

SUBMITTER: Schutz L 

PROVIDER: S-EPMC12720205 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature