Probability of vertical HIV transmission: a systematic review and meta-regression.

ABSTRACT:

Background

Eliminating HIV vertical transmission is a global priority and monitored by estimating paediatric HIV infections with the UNAIDS-supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART) service-delivery models and first-line regimens aimed to reduce vertical transmission probabilities. We did a systematic review and meta-analysis to estimate vertical transmission probabilities by maternal immunological and treatment status.

Methods

In this systematic review and meta-regression, we combined an updated systematic review with previous data in meta-regression models to estimate vertical transmission probabilities and determinants. We searched PubMed, Embase, the Global Health Database, WHO Global Index Medicus, CINAHL Co

SUBMITTER: Walters MK 

PROVIDER: S-EPMC12720210 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature