Latent classes of mental health disorders and their associations with polymorphisms of 5HTTLPR and BDNF in a Chilean primary care population.

ABSTRACT: This study explored the association between serotonin transporter gene (5HTTLPR) and brain-derived neurotrophic factor gene (BDNF) polymorphisms with mental health disorders in a Chilean primary care population using latent class analysis. The sample included 789 adults genotyped for 5HTTLPR and BDNF, who were assessed for psychiatric diagnoses using the Composite International Diagnostic Interview (CIDI). Two distinct mental health profiles emerged: a high psychiatric comorbidity group, marked by a high prevalence of anxiety and stress-related disorders, and a low comorbidity group. The study found that the L'/L' polymorphism of the serotonin transporter gene was associated with a reduced risk of belonging to the high-comorbidity group, particularly when paired with the GG polymorphism of

SUBMITTER: Moraga-Escobar E 

PROVIDER: S-EPMC12720213 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature