Hepatitis B Virus Genomic Variability & HBV-Related Disease Outcomes: A Molecular Epidemiology Perspective.

ABSTRACT: HBV infection remains a major global health challenge, characterized by diverse genotypes with distinct geographical distributions and clinical outcomes. Comprehensive analysis of HBV genomic variability and its association with disease progression is essential for improving clinical management and public health strategies. This study aimed to systematically investigate HBV genotype, subgenotype, phylogenetic clade and serotype distribution, phylogenetic clustering, and clinically relevant mutations, focusing on their potential association with diverse disease outcomes. We analyzed 1001 HBV genomic sequences with available clinical metadata from public databases. Advanced bioinformatics tools were employed for genotype/subgenotype classification, recombination detection, and phylogenetic c

SUBMITTER: Bousali M 

PROVIDER: S-EPMC12720221 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature