Disrupted Energetic and Entropic Landscape in Individuals With Mild Cognitive Impairment: Insights From Network Control Theory.

ABSTRACT: The energetic and entropic organization of the brain's functional activity in mild cognitive impairment (MCI) has yet to be fully characterized. Network Control Theory (NCT) is a multi-modal approach that captures alterations in the brain's energetic landscape by combining the brain's functional activity and the structural connectome. Entropy is another complementary metric that can quantify the complexity and predictability in a neural time series, offering insights into the brain's dynamic functional activity. Our study aims to explore the differences in the brain's energetic and entropic landscape between people with MCI and healthy controls (HC). Four hundred ninety-nine HC and 55 MCI patients were included. First, k-means clustering was applied to functional MRI (fMRI) time series to

SUBMITTER: Neumann D 

PROVIDER: S-EPMC12720285 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature