StructRMDB: A database of RNA modification sites that affect RNA secondary structure.

ABSTRACT: Post-transcriptional RNA modifications, prevalent in multiple RNA species such as mRNA, rRNA, and tRNA, play a significant role in biological processes by altering RNA structures. With recent advancements in prediction algorithms, it is possible to predict RNA secondary structure for sequences containing modified bases. In this study, we introduce StructRMDB, the first database designed to characterize the impact of chemical modifications on RNA secondary structure. StructRMDB comprises more than 880,000 RNA modification sites and their structural impacts, including N ⁶ -Methyladenosine (m⁶A), pseudouridine (Ψ), and adenosine-to-inosine editing (A-to-I) from nine species in both pre-RNA and mature RNA. Two RNA secondary structure prediction tools (RNAstr

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12720313 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature