Prostate Cancer Risk and DNA Mismatch Repair Deficiency Among Lynch Syndrome Patients.

ABSTRACT:

Background and objective

Lynch syndrome (LS) increases the risk of gastrointestinal, endometrial, and other cancers. Recent data suggest that LS also increases the risk of prostate cancer (PC). Our study aims to characterize the incidence and the clinical and molecular features of PC in LS.

Methods

Adult males with LS were identified from an institutional genetic testing registry. PC diagnoses were identified, and tumor tissue was assessed for DNA mismatch repair deficiency (dMMR) by immunohistochemistry.

Key findings and limitations

Among 235 adult males with LS, 35 were diagnosed with PC at a median age of 60 yr (interquartile range: 58-69.5). By age 75 yr, the cumulative incidence of any PC and clinically significant PC was 38% (95% confidence interval [CI]: 27-50%

SUBMITTER: Rodgers-Fouche L 

PROVIDER: S-EPMC12720340 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature