Integrated chemical exposome-metabolome profiling of follicular fluid and associations with fertility outcomes during assisted reproduction.

ABSTRACT: Many endocrine-disrupting chemicals have been linked to impaired ovarian function and fertility. However, most research has focused on small numbers of known chemicals in blood or urine. We aimed to measure the untargeted chemical exposome and metabolome in follicular fluid, a more toxicologically relevant reproductive biofluid, and evaluate associations with outcomes of controlled ovarian stimulation. Follicular fluid was collected from 82 patients undergoing egg retrieval for assisted reproduction in Atlanta and analyzed using untargeted gas (GC) and liquid (LC) chromatography with high-resolution mass spectrometry (HRMS). In single-chemical regression and mixture models (weighted quantile sum with random subsets), we estimated associations of chemicals with retrieved oocyte count, adjus

SUBMITTER: Young AS 

PROVIDER: S-EPMC12720341 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature