Dextran-modified dissolving microneedle patches for effective amelioration of psoriasis through transdermal delivery of hesperidin.

ABSTRACT: Psoriasis is a chronic, multifactorial, proliferative inflammatory skin disease characterized by immune-mediated relapsing and remitting phases. Topical treatments for mild to moderate psoriasis, as well as systemic treatments for severe cases, can be insufficiently effective and are often associated with significant side effects. The primary objective of this study was to develop a dissolvable microneedle patch containing the flavonoid hesperidin within a polymeric matrix composed of dextran modified polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) aiming to achieve effective control of psoriasis symptoms. The innovative laser ablation technique used in master mold fabrication resulted in well-structured pyramidal arrays, as evidenced by SEM images of the microneedle patches (MNPs).

SUBMITTER: Etemadi N 

PROVIDER: S-EPMC12720357 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature