Cyclin-dependent kinase inhibitor-1 deficiency enhances bone destruction in a mouse model of arthritis.

ABSTRACT: Rheumatoid arthritis (RA) causes bone destruction by activating inflammatory cytokines and osteoclasts. Cyclin-dependent kinase inhibitor 1 (p21), a cell cycle regulator, may influence this process; however, its role remains unclear. Therefore, we investigated the effect and potential mechanisms of p21 deficiency in bone loss in a mouse model of arthritis. Collagen antibody-induced arthritis (CAIA) was established in p21 knockout (p21 ^-/- ) and wild-type mice. Bone destruction was analyzed using histology, micro-computed tomography, and bone strength testing; osteoclast formation and activity were evaluated using tartrate-resistant acid phosphatase (TRAP) staining and immunohistochemistry for cathepsin K. The expression of inflammatory cytokines and osteoclast-rela

SUBMITTER: Wada K 

PROVIDER: S-EPMC12720362 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature