Distinct cortical morphometric inverse divergence changes in Parkinson's disease correlate with transcriptional expression patterns.

ABSTRACT: Growing evidence shows that parkinson's disease (PD) is a heterogeneous neurodegenerative disorder associated with region-specific changes in brain anatomy. However, the genetic mechanisms underlining these abnormalities are unclear. We aim to investigate PD neuroanatomical subtypes and uncover the specific brain-wide gene expression associated with morphometric abnormalities in each PD subtype. The morphometric inverse divergence (MIND) algorithm was used to quantify the morphological similarity based on multiple MRI features in 127 patients with PD and 101 healthy controls (HC). Then, heterogeneity through discriminant analysis (HYDRA) was employed to investigate the PD subtypes based on the MIND strength. Intergroup comparisons were conducted to assess MIND strength and clinical behavio

SUBMITTER: Zou T 

PROVIDER: S-EPMC12720368 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature