Cholangiocyte ciliary defects induce sustained epidermal growth factor receptor signaling.

ABSTRACT:

Background and aims

The primary cilium, an organelle that protrudes from cell surfaces, is essential for sensing extracellular signals. With disturbed cellular communication and chronic liver pathologies, this organelle's dysfunctions have been linked to disorders, including polycystic liver disease and cholangiocarcinoma. The goal of this study was to elucidate the relationship between primary cilia and the crucial regulator of cellular proliferation, the epidermal growth factor receptor (EGFR) signaling pathway, which has been associated with various clinical conditions.

Approach and results

The study identified aberrant EGFR signaling pathways in cholangiocytes lacking functional primary cilia using liver-specific intraflagellar transport 88 knockout mice, a Pkhd1 mutant

SUBMITTER: Pant K 

PROVIDER: S-EPMC12720392 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature