Predicting dysthyroid optic neuropathy in moderate-to-severe thyroid eye disease: a clinically applicable nomogram.

ABSTRACT:

Objective

Dysthyroid optic neuropathy (DON) is a severe complication of thyroid eye disease (TED) with limited early detection methods. This study aimed to investigate the clinical characteristics of patients with TED who developed DON and to establish a predictive model for early identification of high-risk cases.

Methods

Herein, 257 TED patients were prospectively included, of whom 68 (26.5%) developed DON. All patients were divided into derivation and validation cohorts, and Least Absolute Shrinkage and Selection Operator (LASSO) regression and logistic regression analyses were applied to identify clinical factors and construct a prediction model.

Results

In the derivation cohort (185 TED patients), 49 (26.5%) developed DON. DON patients showed significantly higher

SUBMITTER: Hu R 

PROVIDER: S-EPMC12720399 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature