Investigating the mechanism of aluminum resistance conferred by aluminum resistance protein 1.

ABSTRACT: Aluminum does not play any role in essential biological processes, but in acidic conditions it becomes biologically reactive and highly toxic even at low concentrations. Eukaryotes have developed numerous strategies for detoxification, one of which relies on membrane proteins. Fungi possess so-called aluminum resistance proteins (Alr1/2p), which are distant homologs of CorA Mg²⁺-channels but are claimed to confer resistance to aluminum. However, the mechanism behind this resistance remains poorly understood. In this study we aimed to conduct a thorough functional and structural characterization of Alr1p from Pichia pastoris (PpAlr1p). Our results confirm that PpAlr1p similar to other members of the CorA family functions as a pentamer and can mediate Zn²⁺ and Cd²⁺

SUBMITTER: Stehantsev P 

PROVIDER: S-EPMC12720413 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature