A novel BMSC-derived Exosomal circrna promotes angiogenesis by targeting miR-34a-5p to regulate Piezo1.

ABSTRACT:

Background

Steroid-induced osteonecrosis of the femoral head (SONFH) is characterized by impaired angiogenesis and bone remodeling, ultimately leading to joint dysfunction. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) carry bioactive molecules, including circular RNAs (circRNAs), which play crucial roles in regulating angiogenesis and tissue repair. This study investigated the role of a novel BMSC-derived exosomal circRNA (novel_circ_0001686) in promoting angiogenesis through a competing endogenous RNA (ceRNA) mechanism, targeting the miR-34a-5p/Piezo1 axis.

Methods

This study employed a comprehensive approach to determine the roles of circRNAs in BMSC-derived exosomes from patients with SONFH. High-throughput sequencing identified circRNA profiles, with

SUBMITTER: Wu T 

PROVIDER: S-EPMC12720445 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature